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plant cells survive but stop dividing upon dna damage




image: green spots indicate a transcription factor that accumulates and inhibits cell division upon dna damage. researchers found an indispensable role of the transcription factor in arresting plant growth under stressful... view more credit: masaaki umeda(nara, japan) the cell cycle is the system...



visualization of transcription initiation at single-molecule resolution




a novel approach developed at the friedrich miescher institute for biomedical research (fmi) has allowed scientists in dirk schübeler's group to dissect and quantify the individual steps of transcription initiation. unexpectedly, they observed that rna polymerases frequently dissociate from the dna...



transcription factor expression tied to medial amygdala neuronal id, sex-specifi




image: this is joshua g. corbin, ph.d., principal investigator in the center for neuroscience research at children's national health system. view more credit: children's national health systemwashington - neurons derived from two different types of precursor cells that later develop into neurons in...



crystal structure reveals new details of nonstandard rna transcription




image: schematic of alternative pathways for transcription elongation complex formation. during canonical transcription (left) the growing strand of rna extends toward the rna exit channel of rna polymerase. new, high-resolution crystal... view more credit: murakami laboratory, penn state universi...



excess transcription factor heat shock factor 1 can delay embryonic neural migra




image: kazue hashimoto-torii, ph.d., principal investigator in the center for neuroscience research at children's national health system and senior author of the paper published may 2 in nature communications, and her... view more credit: children's national health systemwashington - transcription...



rattling dna hustles transcribers to targets




imagine if a dense thicket didn't obstruct your path but instead picked you up and shuttled you through the forest. that's what tightly packed dna might be doing with important life molecules to get them where they're needed on time.new simulations of dna as a transport conduit could shatter the way...



rattling dna hustles transcribers to targets




naturally occurring dna is in constant motion, researchers hypothesize, and transports large transcription factors (depicted in green) through its tangles until they reach sites where they bind and carry out their activity. here a still image from a very large, unique simulation. credit: georgia tec...



preeclampsia triggered by an overdose of gene activity




preeclampsia is the most dangerous form of hypertension during a pregnancy and can be fatal for both mother and child. though it is known to originate in the placenta, the root causes remain largely a mystery. an international research team led by the max delbrück center for molecular medicine (mdc...



unexpected regulation of transcription factors critical to development




a team of developmental biologists at the university of massachusetts amherst led by dominique alfandari, with others at mit, report in a new paper that they have for the first time described how two transcription factors that are "absolutely essential for human development" are regulated by a cell ...



study finds n-alpha-acetyltransferase d (natd) promotes lung cancer progression




researchers at nanjing university and their collaborators have found that natd, which mediates n-alpha-terminal acetylation (nt-acetylation) of histone h4, promotes lung cancer progression by preventing histone h4 serine phosphorylation to activate the transcription factor slug, a key regulator of t...



a protein that extends life of yeast cells




image: this is baker's yeast saccharomyces cerevisiae. view more credit: (image: university of basel/sni/nano imaging lab)to understand and control aging is the aspiration of many scientists. researchers at the biozentrum of the university of basel have now discovered that the protein gcn4 decreas...



ai takes the headaches out of transcribing voice recordings




ask many interviewers about their least favorite part of the job and they'll almost always point to transcription. it can take hours to turn even a short chat into text, which is a serious pain for everyone from reporters to police interrogators. china tech giant baidu may have a smarter approach: a...



researchers show how a cancer gene protects genome organization




chapel hill, nc - unc school of medicine researchers have cracked a long-standing mystery about an important enzyme found in virtually all organisms other than bacteria. the basic science finding may have implications for understanding cancer development and how to halt it.researchers have known tha...



anti-malaria drugs: potential new target identified




a newly described protein could be an effective target for combatting drug-resistant malaria parasites. the protein, the transcription factor pfap2-i, regulates a number of genes involved with the parasite's invasion of red blood cells, a critical part of the parasite's complex life cycle that could...



accessing dna in the cell's powerhouse to treat disease




a schematic illustration of a mitochondria-specific dna-based synthetic ligand, called mito-pips that selectively read a target dna sequence and alter gene transcription. credit: kyoto university icemsfor the first time, a synthetic compound has been made that can bind to dna in the cells' energy po...



accessing dna in the cell's powerhouse to treat disease




image: this is a schematic illustration of a mitochondria-specific dna-based synthetic ligand, called mito-pips that selectively read a target dna sequence and alter gene transcription. view more credit: kyoto university icemsfor the first time, a synthetic compound has been made that can bind to ...



how to enable 2-factor authentication on iphone and ipad




how do you set up apple's two-factor authentication and how do you get verification codes? here's what you need to know!updated april 2017: as part of ios 10.3, set up assistant, the wizard that walks you through signing in on a new or newly updated iphone or ipad, will now prompt you to enable 2-fa...



transcription ensemble | athens | may 10 | what’s on




monday may 8, 2017 what’s on | greek editionclassifiedssubscriptionsfavoritesno favoritestwitterfacebooktermwhat's on 20:20 transcription ensemble | athens | may 10tags:musicthe transcription ensemble – comprising yiorgos kandylidis on violin, cellist christos grimpas and nikos zafranas on piano...



apple prompting ios 10.3 users to enable two-factor authentication w/ push notif




apple has started prompting ios 10.3 beta users to enable two-factor authentication with a new push notification. the prompt has only started appearing over the last 24 hours or so and seems to have hit most users in the middle of the night last night.if you swipe on the notification, you’re taken...



sulforaphane, a phytochemical in broccoli sprouts, ameliorates obesity




image: the two functions of sulforaphane uncovered by the current study are; 1) ameliorating obesity by adipose tissue browning to augment energy consumption and 2) improving 'high-fat' gut bacterial flora and... view more credit: kanazawa university[background]sulforaphane*1, a phytochemical conta...



using networks to understand tissue-specific gene regulation




researchers at brigham and women's hospital have discerned that different tissue functions arise from a core biological machinery that is largely shared across tissues, rather than from their own individual regulators. in a paper published in cell reports, kimberly glass, phd, of the channing divisi...



using networks to understand tissue-specific gene regulation




researchers at brigham and women's hospital have discerned that different tissue functions arise from a core biological machinery that is largely shared across tissues, rather than from their own individual regulators. in a paper published in cell reports, kimberly glass, phd, of the channing divisi...



two-factor authentication comes to instagram




how do i set up and use instagram's new two-factor authentication feature?two-factor authentication is now available to everyone. this tool adds an extra layer of security to your instagram account by requiring a code every time you log in. tap the gear icon on your profile and choose two-factor aut...



mtv renews fear factor for second season




there's about to be some new ludicrous (see what we did there?) fear factor challenges: the series is returning for season 2!mtv announced today (in advance of tonight's season finale) that the reinvented ludacris-hosted program will return with 20 new episodes in 2018. more creepy critters and scar...



two-factor authentication: everything you need to know!




hackers are too good, and security systems flawed. longer complicated passwords created by generators like safari's icloud keychain or third party apps like lastpass or 1password can help, but the best way to lock down your accounts is to add extra security options for two-step or two-factor (2fa) a...