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scientists light the way for immune system to attack cancer




the science behind harnessing the immune system to fight cancer is complicated, but a university of rochester medical center laboratory discovered a simple, practical way to use light and optics to steer killer immune cells toward tumors. in a study published by the online journal nature communicati...



scientists discover how obesity stops 'guardian immune cells' from doing their j




scientists have uncovered the physiological mechanics underlying inflammation and obesity by tracking the actions of 'guardian immune cells' in response to changes in diet. they believe their work may herald a new era of research now that they have new therapeutic targets to prevent and control obes...



subduing the rebellion: unmasking rogue cells in the immune system




the immune system is a formidable defense against microbial intruders, identifying and eliminating the threats through an extremely intricate and adaptable network of specialized cells. however, a system of such mind-boggling complexity is also prone to misfire. due to genetic mutations for example,...



study highlights possible achilles' heel in key immune memory cells




the capacity for memory isn't exclusive to the brain. the immune system, with its sprawling network of diverse cell types, can recall the pathogens it meets, helping it to swiftly neutralize those intruders upon future encounters. for the last several years, bwh's thomas kupper, md, chair of the dep...



the molecular underpinnings of t cell exhaustion




image: prolonged overactivity of killer t cells summoned to a tumor or infection site can render them useless to dispatch invaders, a cellular state immunologists call "exhaustion. " view more credit: courtesy: national institutes of health- https://www.flickr.com/photos/nihgov/20673870162/in/album...



immune cells derived from specialised progenitors




image: prof. dr. joachim schultze, patrick günther and dr. andreas schlitzer from limes-institute at university of bonn. view more credit: © photo: volker lannert/uni bonndendritic cells are gatekeepers of immunity and are crucial for the detection and initiation of immunity against pathogens an...



cancer commandeers immature immune cells to aid its successful spread




image: dr. hasan korkaya and graduate student eunmi lee. view more credit: phil jones, senior augusta university photographer augusta, ga. (april 6, 2017) - more typically, these immature immune cells might help us fight cancer, but scientists have now shown cancer can commandeer the cells to help ...



study examines effects of spaceflight on immune system




expedition 30 crew members dan burbank and andre kuiper perform blood draws for the integrated immune investigation. data collected during the functional immune study will build upon findings from this investigation. credit: nasagetting sick isn't fun for anyone, but it could be especially taxing fo...



advancing cancer immunotherapy with computer simulations and data analysis




image: this is a scanning electron micrograph of a human t lymphocyte (also called a t cell) from the immune system of a healthy donor. immunotherapy fights cancer by supercharging the... view more credit: niaidthe body has a natural way of fighting cancer - it's called the immune system, and it i...



designer viruses stimulate the immune system to fight cancer




image: this is a view of a modified lymphocytic choriomeningitis virus (lcmv). view more credit: © unige / doron merklerswiss scientists from the university of geneva (unige), switzerland, and the university of basel have created artificial viruses that can be used to target cancer. these designe...



scientists rejuvenate blood by reprogramming cells




like it or not, your body gradually loses its capacity for producing blood as you age -- that's why immune deficiencies, leukemia and other blood conditions become more likely with time. scientists may have found a way to turn back the clock, though. they've found a way to rejuvenate blood by reprog...



lab mice may not be effective models for immunology research




the findings have implications for all aspects of medical and scientific research because laboratory mice underpin studies whose results have a transformative effect on human and animal lives through vaccination and other immune-based therapies.professor mark viney and colleagues from the university...



rutgers researchers develop protocol to analyze many cells at once




rutgers researchers have developed a new way to analyze hundreds of thousands of cells at once, which could lead to faster and more accurate diagnoses of illnesses, including tuberculosis and cancers.with the new fish-flow protocol, researchers are able to evaluate multitudes of cells at once for te...



combination immunotherapy effective for advanced prostate cancer




advanced prostate cancer resistant to castration therapy appears to respond well to a combination of immune checkpoint blockades and treatments that target certain immune-busting cells commonly associated with poor patient prognosis and therapy resistance.researchers at the university of texas md an...



labeling a bacterial cell 'jacket': team invents scientific method to track cell




you have three to five pounds of bacteria living in and on your body right now. that's some 38 trillion bacteria, researchers estimate. your immune system has to manage all of them, sorting out the good from the bad bugs.



scientists use gene editing to eliminate hiv dna in live mice




the team used three different types of mice for their most recent experiments. first type is infected with latent hiv lurking in its cells, the same type they used for their trials in 2016, while the second one has actively replicating hiv in its system. the last type is grafted with human immune ce...



patients' immune system may influence effectiveness of cancer immunotherapy




washington, april 2, 2017 - higher or lower levels of certain immune cells in cancer patients may be associated with how well they respond to immunotherapy, according to preliminary results of a study conducted by researchers at the university of pittsburgh cancer institute (upci). the findings will...



immune system can spot tell-tale change in identity of cancer antigens -- study




a new study has identified novel mechanisms whereby t cells may be able to distinguish an emerging class of targets specifically increased on cancer cells. the study, carried out by researchers from the university of birmingham and the university of virginia, and published today in oncotarget, focus...



an inflammatory inference | eurekalert! science news




image: single cell tracking trajectories (flow is bottom to top) of cells expressing e-selectin (red spheres) rolling over cd44 purified from t cells over time. view more credit: © 2017 jasmeen merzabanthe protein tags that adorn immune cells and engage with receptors to promote inflammation in t...



new drug therapy could improve brain function and life expectancy of als patient




beer-sheva, israel... may 23, 2017 - ben-gurion university of the negev (bgu) researchers are developing a new therapy for amyotrophic lateral sclerosis (als) using part of an existing fda-approved drug that restores the central nervous system's (cns) immune defenses and increases life expectancy.al...



new finding affecting immune reconstitution related to b cells




researchers from the children's center for cancer and blood diseases at children's hospital los angeles examined the mechanisms of b cell immune reconstitution in pediatric patients who had undergone bone marrow transplantation and discovered a disruption in the maturation of b cells - critical to t...



new role for immune cells in preventing diabetes and hypertension




image: immune cells which are reduced in number by obesity could be a new target to treat diseases such as type 2 diabetes and hypertension that affect overweight people, according to... view more credit: the university of manchesterimmune cells which are reduced in number by obesity could be a new...



genetic variant linked to overactive inflammatory response




researchers at cardiff university have discovered that genetic variation is the reason why some immune systems overreact to viruses.previous research had already revealed that a gene called ifitm3 influences how sensitive people are to the influenza virus, with a variant form of the gene making cell...



researchers develop technique to track yellow fever virus replication




the liver of a mouse whose immune cells lack the immune signaling component known as stat1 shows severe lymphocyte infiltration and inflammation, as well as necrosis, after infection with yfv-17d. credit: florian douam and alexander ploss, princeton universityresearchers from princeton university's ...



two biomarkers appear to predict course of ipf




ats 2017, washington, dc -- two t cell biomarkers appear to predict the survival trajectory of patients with idiopathic pulmonary fibrosis (ipf), a lung disease that has a varied, but ultimately devastating, impact on patients, according to new research presented at the ats 2017 international confer...