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new structural studies reveal workings of a molecular pump that ejects cancer dr




sometimes cells resist medication by spitting it back out. cancer cells, in particular, have a reputation for defiantly expelling the chemotherapy drugs meant to kill them. researchers at the rockefeller university have shed new light on a molecular pump that makes this possible, by determining its ...



new structural studies reveal workings of a molecular pump that ejects cancer dr




the anatomy of the pump's pocket for carrying cargo (highlighted in blue) explains how this molecular machine is able to grab and eject a wide range of substances, including cancer drugs. credit: ella maru studiosometimes cells resist medication by spitting it back out. cancer cells, in particular, ...



new structural studies reveal workings of a molecular pump that ejects cancer dr




image: the anatomy of the pump's pocket for carrying cargo (highlighted in blue) explains how this molecular machine is able to grab and eject a wide range of substances, including cancer... view more credit: ella maru studiosometimes cells resist medication by spitting it back out. cancer cells, i...



soy may help breast cancer patients to live longer




maximilian stock ltd.—getty imagesthere is perhaps no more complicated and fraught connection between cancer and food than the one between breast cancer and soy.when studies first revealed that women in asian countries who eat a significant amount of soy daily were less likely to die of breast can...



a multidrug efflux pump in motion




researchers at vanderbilt university medical center have mapped the conformational changes that occur in a protein "notorious" for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching the central nervous system.



two migration proteins boost predictive value of pancreatic cancer biomarker




image: this is ann killary, ph.d. view more credit: md anderson cancer centeradding two blood-borne proteins associated with cancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from the university of te...



genetic analysis better explains how uterine cancers resist treatment




researchers have charted the complex molecular biology of uterine carcinosarcoma, a rare and aggressive gynecologic cancer, according to a study published on march 13 in cancer cell. using this new collection of genomic information, physicians will be better able to determine the specific genetic fi...



unexpected oxidation state for molecular plutonium discovered




researchers at los alamos national laboratory in collaboration with the university of california - irvine (uci) have uncovered a significant new chemical attribute of plutonium, the identification and structural verification of the +2 oxidation state in a molecular system.



drug resistance of cancer cells crucially affected expression levels of abc-tran




how is drug resistance of cancer cells affected by abc-transporters? a new research paper, published in the open access journal biodiscovery, looks at the complex relationship between the second generation of tyrosine kinase inhibitor (tki) - dasatinib (das), and the expression of atp-binding casset...



drug combination delivered by nanoparticles may help in melanoma treatment




the first of a new class of medication that delivers a combination of drugs by nanoparticle may keep melanoma from becoming resistant to treatment, according to penn state college of medicine researchers. celeplum-777 combines a special ratio of the drugs celecoxib, an anti-inflammatory, and plumbag...



molecule stops fatal pediatric brain tumor




chicago --- northwestern medicine scientists have found a molecule that stops the growth of an aggressive pediatric brain tumor. the tumor is always fatal and primarily strikes children under 10 years old. every year, about 300 children under the age of 10 years old in the u.s. develop a tumor refer...



molecular structure of the cell nucleoskeleton revealed for the first time




using 3-d electron microscopy, structural biologists from the university of zurich succeeded in elucidating the architecture of the lamina of the cell nucleus at molecular resolution for the first time. this scaffold stabilizes the cell nucleus in higher eukaryotes and is involved in organizing, act...



biocon and others win drug battle in delhi high court




a two-judge bench of the delhi high court on march 3 lifted an earlier stay order of the same court on the issue of marketing and sale of generic drug biosimilar of roche’s breast cancer drug ‘trastuzumab’ (group name). the appeal was filed by indian pharma major biocon and other pharmaceutic...



soy food consumption linked to prolonged survival in some breast cancer patients




new research indicates that dietary soy products are safe and even beneficial for women diagnosed with breast cancer. published early online in cancer, a peer-reviewed journal of the american cancer society, the findings may help resolve controversies over soy's potential link to breast cancer outco...



joe biden at sxsw: vows to work with donald trump on cancer




at the annual digital, music and entertainment festival in austin, tex., former vice president joe biden described how his role in heading up the white house moonshot on cancer came about — from a comment he made to former president obama that his only regret in not running for the presidency was ...



targeting a tumor trigger | eurekalert! science news




heidelberg, 15 march 2017 - many cancer patients that receive chemotherapy go into remission at first, but relapse after treatment is discontinued. there is increasing evidence that this is due to the presence of cancer stem cells -- cells that reproduce indefinitely and may seed new tumors. a resea...



fluciclovine pet/ct improves radiotherapy targeting for recurrent prostate cance




image: ctvpost (red) = ctvpre (yellow) union ctvpet (pink). also shown (upper right corner) are the pre (square) vs post (triangle) dose volume histograms for ptv1, ptv2, rectum, bladder, and penile... view more credit: ashesh b. jani, md, and david schuster, md, emory university.reston, va. (march...



in battle for real estate, a disordered protein wins out




image: professor peter wright, professor jane dyson and research associate rebecca berlow led the study at the scripps research institute. (photo by madeline mccurry-schmidt.) view more credit: the scripps research institutela jolla, ca - march 8, 2017 - research findings that first had scientists ...



scientists stimulate immune system, stop cancer growth




a chemical found in tumors may help stop tumor growth, according to a new study.researchers at the university of illinois at chicago report that increasing expression of a chemical cytokine called light in mice with colon cancer activated the immune system's natural cancer-killing t-cells and caused...



lung cancer may go undetected in kidney cancer patients




image: (l to r): dr. james brugarolas, dr. isaac bowman, dr. ivan pedrosa, and dr. payal kapur studied lung cancer tumors in kidney cancer patients. view more credit: ut southwesterndallas - march 7, 2017 - could lung cancer be hiding in kidney cancer patients? researchers with the harold c. simmon...



newly discovered vulnerability in an aggressive breast cancer provides therapeut




triple-negative breast cancer quickly becomes resistant to current therapies, leaving patients no therapeutic options. bidmc researchers discovered that tnbc cells increase production of pyrimidine nucleotides in response to traditional chemotherapy. discovery represents a vulnerability that can be ...



on the path toward molecular robots




the crystals repeatedly flip under a blue light. credit: hokkaido universityscientists in japan have developed light-powered molecular motors that repetitively bend and unbend, bringing us closer to molecular robots. researchers around the world are trying to mimic cellular systems to develop molecu...



how rats could lead to autism drugs that actually work




clinical trials with mice have mostly failed, but the bigger, smarter rodents have more to reveal about human brains and behavior.



solid metal has 'structural memory' of its liquid state




this recovered bismuth sample has a rhombohedral structure and contains liquid structural motifs after deep melting at high pressures. the surprising structural memory effect in the molten state is responsible for the unexpected change from magnetic repulsion to magnetic attraction in bismuth. credi...



researchers discover how breast cancer mutation in brca1 causes protein to self-




image: deborah kelly, a structural biologist with the virginia tech carilion research institute, explained how the brca1 gene loses its tumor-fighting potency. view more credit: david hungate/virginia tech carilionof the more than 3 million people with breast cancer in the united stated, about 10 p...