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new enzyme like tool lets chemists modify hard to reach spots on drug molecules - Search

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new enzyme-like tool lets chemists modify hard-to-reach spots on drug molecules




march 8, 2017 - chemists at the scripps research institute (tsri) have devised a versatile molecule-building tool for creating new drugs and other chemical products.



new tool to map rna-dna interactions could help researchers translate gene seque




bioengineers at the university of california san diego have developed a new tool to identify interactions between rna and dna molecules. the tool, called margi (mapping rna genome interactions), is the first technology that's capable of providing a full account of all the rna molecules that interact...



how molecular machines may drive the future of disease detection and drug delive




image: university of alberta scientists have created molecular nanomachines that work in living cells. the work is expected to make inroads on improved disease detection and drug delivery in the future. view more credit: melissa fabriziouniversity of alberta scientists have pulled into the lead in ...



new tool to map rna-dna interactions could help researchers translate gene seque




artistic rendering of rna-dna interactions. a 3-d structure of tightly coiled dna is depicted as the body of a dragon in chinese myth. interacting rnas are depicted as hairs, whiskers and claws, which are essential for the dragon to function. credit: victor o. leshykbioengineers at the university of...



decoding the genome's cryptic language




image: artistic rendering of rna-dna interactions. a 3-d structure of tightly coiled dna is depicted as the body of a dragon in chinese myth. interacting rnas are depicted as hairs, whiskers... view more credit: victor o. leshykbioengineers at the university of california san diego have developed a...



a novel method for designing fluorescent probes improves imaging of complex mole




this image illustrates how the probe recognizes and responds to nadh based on the two-step sensing process. the boronic acid-based probe can specifically ‘hook’ nadh and then accelerate a reaction between probe and nadh that creates the fluorescent signal. credit: a*star singapore bioimaging con...



cholesterol-processing enzyme protects from debilitating brain lesions




an enzyme that helps break down cholesterol may also be a therapeutic target to stave off neurologic diseases, including alzheimer's and a rare genetic disorder, according to a new study published in the journal of biological chemistry. researchers from case western reserve university school of medi...



'oleo sponge' may be the key to cleaning up after oil spills




unlike other clean-up methods, the argonne national laboratory says that the sponge can scrub the entire water column. what's more, the sponge and the oil can be reused. oleo sponge builds on previous research from argonne regarding how a complex structure can retain oil. in this case, it's a cellul...



cholesterol-processing enzyme protects from debilitating brain lesions




an enzyme that helps break down cholesterol may also be a therapeutic target to stave off neurologic diseases, including alzheimer's and a rare genetic disorder, according to a new study published in the journal of biological chemistry. researchers from case western reserve university school of medi...



chemists color world of 3-d crystals with advances in self-assembly




a team of new york university chemists has created self-assembled, three-dimensional dna crystals that can bind a separate, dye-bearing strand—a breakthrough that enhances the functionality of these tiny building blocks. the advance, reported in the journal nature chemistry, offers promise for the...



researchers imitate molecular crowding in cells




image: this image shows an enzymatic reaction inside a nanoreactor, on the left in absence and of a crowding agent and on the right with molecular crowding. view more credit: university of basel, department of chemistryenzymes behave differently in a test tube compared with the molecular scrum of a...



chemists can rapidly purify wastewater with sunlight




chemists have found a way to use sunlight to purify wastewater rapidly and cheaply, and to make self-cleaning materials for buildings.



block copolymer micellization as a protection strategy for dna origami




the precise positioning of individual molecules with respect to one another is fundamentally challenging. dna nanotechnology enables the synthesis of nanometer-sized objects with programmable shapes out of many chemically produced dna fragments. one of the most widely used methods in this field is c...



useful design tool: webgradients.com




tools, i think we are having the luxury of a huge range of variety of tools to increase your productivity in your workflow as a designer and even as a developer. with having a huge quantity of tools, it’s hard to handpicked which one could work best for you but to actually try them. here’s a sta...



researchers push the limits of organic synthesis




a dendritic molecule is one that grows by branching in several directions from its center core. at each branching point, the molecule branches again into a new generation. these molecules can be used for a broad range of biomedical applications, including gene and drug delivery.



new tool, rodeo, promises to capture the breadth of microbial biosynthetic poten




in an age of booming biotechnology, it might be easy to forget how much we still rely on the bounty of the natural world. some microbes make us sick, some keep us healthy, while others continue to give us some of our best cures in the form of naturally occurring products such as penicillin and tetra...



drug resistance of cancer cells crucially affected expression levels of abc-tran




how is drug resistance of cancer cells affected by abc-transporters? a new research paper, published in the open access journal biodiscovery, looks at the complex relationship between the second generation of tyrosine kinase inhibitor (tki) - dasatinib (das), and the expression of atp-binding casset...



novel antibiotic combination therapy overcomes deadly drug-resistant bacteria




researchers have known that part of the challenge in treating penicillin-resistant infections lies in understanding the way bacteria inactivate penicillin antibiotics. the enzymes that do this, beta-lactamases, chop up the antibiotics rendering them useless. one particularly problematic group of bac...



researchers push the limits of organic synthesis




a dendritic molecule is one that grows by branching in several directions from its center core. at each branching point, the molecule branches again into a new generation. these molecules can be used for a broad range of biomedical applications, including gene and drug delivery. in 1983, nobel laure...



when ions and molecules cluster




the electric charge of atoms or molecules zaps science's ability to predict how these ions will behave when combined with others. different ions with the same charge cause different effects. how an ion behaves when isolated under an analytical instrument can differ from how it behaves in the environ...



penn researchers push the limits of organic synthesis




a dendritic molecule is one that grows by branching in several directions from its center core. at each branching point, the molecule branches again into a new generation. these molecules can be used for a broad range of biomedical applications, including gene and drug delivery.in 1983, nobel laurea...



apple cracking down on developers who use sdks like rollout to update apps witho




apple today has started informing developers that use “hot code push” sdks that it will soon start rejecting their applications. in a thread on the apple developer forums, developers are reporting that they have started receiving messages from the company explaining that the code must be remov...



silicon valley computational drug startup takes on glaucoma




about a year ago i met two silicon valley entrepreneurs named andrew radin, whose matching names generated competition over an internet domain, a connection, and eventually, a company. the startup is called, twoxar, an abbreviation of “two times andrew radin.” the pair presented an ambitious a...



hard drives of the future could be made of dna




there are several advantages to using dna. it's a lot smaller than traditional media; a single gram can fit 215,000 times more data than a one terabyte hard drive, the atlantic notes. it's also incredibly durable. scientists are using dna thousands of years old to de-extinct wooly mammoths, for exam...



how to make your own ethernet cable




you can make your own ethernet cable to achieve lengths that are more useful and save some money in the long run. here's how.whether you want to make some cabling of a specific length or just wish to have a little more fun than picking up ethernet cables from your local store, it's actually an easy ...