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nanoparticle targets kidney disease for drug delivery




remember the scene in the movie mission: impossible when tom cruise has to sneak into the vault? he had to do all sorts of moves to avoid detection. that's what it's like to sneak a targeted drug into a kidney and keep it from getting eliminated from the body.



nanoparticle targets kidney disease for drug delivery




august 21, 2018 , university of southern californiananoparticles move past the glomerular filtration barrier of the kidney to target diseased cells. credit: illustrator: yekaterina (katya) kadyshevskaya from the usc bridge institute at the michelson center for convergent bioscienceremember the scene...



new findings on tolvaptan as autosomal dominant polycystic kidney disease treatm




vicente torres, m.d., ph.d., discusses new findings on tolvaptan as autosomal dominant polycystic kidney disease treatment rochester, minn. - a phase 3 trial studying the effects of tolvaptan has found that the drug slowed the rate of decline in kidney function in patients with the most common form ...



targeting strategy may open door to better cancer drug delivery




image: in the transition from benign to malignant, cancer cells transition from stiff to soft. mechanotargeting harnesses mechanics to improve targeting efficiency of nanparticle-based therapeutic agents. view more credit: zhang lab/vecteezy.combioengineers may be able to use the unique mechanical...



nanoparticle research tested in locusts focuses on new drug-delivery method




engineers at washington university in st. louis used nanoparticles, aerosol technology and locusts in proof of concept research that could someday change the way medicine is delivered to the brain. credit: washington university in st. louisdelivering life-saving drugs directly to the brain in a safe...



device to accelerate drug discovery for kidney diseases




researchers from the department of engineering are collaborating with industry and academia to develop a device to improve the testing of kidney disease drugs.



new methodology helps study of promising targeted drug delivery scaffold




northwestern engineering researchers have developed a new way to manipulate a virus shell that self-assembles from proteins and holds promise as a carrier for disease detection, drug delivery, and vaccinations.



high burden, high cost and low awareness of kidney disease in the united states




image: this is a kidney. view more credit: michigan medicineaccording to an annual data report from the united state renal data system, the overall burden of kidney disease remains high in u.s. with the rates of kidney failure requiring dialysis or kidney transplantation ranking among the highest ...



a simple sniff | eurekalert! science news




delivering life-saving drugs directly to the brain in a safe and effective way is a challenge for medical providers. one key reason: the blood-brain barrier, which protects the brain from tissue-specific drug delivery. methods such as an injection or a pill aren't as precise or immediate as doctors ...



women with pregnancy-related diabetes may be at risk for chronic kidney disease




gestational diabetes may predispose women to early-stage kidney damage, a precursor to chronic kidney disease, according to a study by researchers at the national institutes of health and other institutions. the study appears in diabetes care.gestational diabetes occurs only in pregnancy and results...



stem cell kidney gives hope to sufferers




grant monks was diagnosed with kidney failure as a baby. by the time he was six, he was undergoing regular dialysis treatment before having a kidney transplant at the age of 13, which sent his body into shock.“and about a year later, i had another transplant, off the list, and i got about 6 months...



metabolites altered in chronic kidney disease




san antonio, texas - chronic kidney disease (ckd) affects 1 in 7 people in the united states, according to the u.s. national institute of diabetes & digestive & kidney diseases (niddk). these individuals have a very high risk of cardiovascular disease, and some will also progress to kidney failure r...



protein shown to be predictor of kidney damage in children




high levels of a protein known as supar, which has been shown to be a marker and likely cause of kidney damage, is as reliably predictive in children as in adults, according to results of a study published online today in jama pediatrics, a clinical publication of the american medical association. t...



highly prevalent gene variants in minority populations cause kidney disease




image: representative images of kidney tissue from apol1-g1 and apol1-g2 mice, showing severe scarring of the kidney filter. view more credit: katalin susztak, perelman school of medicine, university of pennsylvaniaphiladelphia - african americans have a heightened risk of developing chronic and en...



intensive blood pressure lowering benefits patients with chronic kidney disease




highlightsin individuals with chronic kidney disease, targeting a systolic blood pressure to



inflammation inhibitor delivered directly to kidneys reverses course of destruct




augusta, ga. (july 30, 2018) - using a manmade version of a human antibody to directly deliver a drug that inhibits a powerful driver of inflammation, can reverse a disease course that often leads to kidney failure and dialysis, investigators report.they have additionally found that it's the powerho...



many patients show signs of chronic kidney disease before diabetes diagnosis




image: dr. csaba kovesdy treats patients and conducts research at the memphis va medical center and university of tennessee health science center. view more credit: warren roseboroughmany patients who will later be diagnosed with diabetes show signs of chronic kidney disease (ckd) even before thei...



massive single-cell survey of kidney cell types reveals new paths to disease




image: this is cell function by disease gene mapping. view more credit: katalin susztak, perelman school of medicine, university of pennsylvaniaphiladelphia - the kidney is a highly complex organ - far beyond a simple filter. its function requires intricate interactions between many highly special...



this drug may stop parkinson's disease, human trials set for 2019




a newly published study details an experimental drug that may be able to stop the progression of parkinson’s disease. the study, which was conducted by researchers with johns hopkins university, saw positive results in lab mice tested with the drugs and similar effects were seen with tests on cult...



a highly sensitive and multi-analytical system for hereditary kidney disease




image: (a) collagen iv alpha-3, alpha-4, and alpha-5 normally form complexes (trimers) and become constituents of the basement membrane in the kidney. in alport syndrome, genetic mutation in one of the... view more credit: dr. kohei omachialport syndrome (as) is a hereditary kidney disease caused ...



a kidney disease's genetic clues are uncovered




new york, ny (march 6, 2017)--researchers have uncovered new genetic clues to understanding iga nephropathy (igan), or berger's disease, an autoimmune kidney disease and a common cause of kidney failure. the findings are relevant to igan as well as other diseases with similar underlying molecular de...



reflux medications linked to chronic kidney disease and kidney failure




highlightsin an analysis of published studies, individuals who used proton pump inhibitors had a 33% increased relative risk of developing chronic kidney disease or kidney failure when compared with non-users.results from the analysis will be presented at asn kidney week 2017 october 31-november 5 a...



how molecular machines may drive the future of disease detection and drug delive




image: university of alberta scientists have created molecular nanomachines that work in living cells. the work is expected to make inroads on improved disease detection and drug delivery in the future. view more credit: melissa fabriziouniversity of alberta scientists have pulled into the lead in ...



university of louisville lab helps discover new disease that causes kidney failu




image: this is jon b. klein, m.d., ph.d., uofl school of medicine vice dean for research and professor of medicine, and james graham brown foundation chair in proteomics. view more credit: university of louisvillelouisville, ky. - researchers at the university of louisville were part of a group th...



john oliver tackes for-profit kidney dialysis companies




john oliver was aware that when he announced that he was dedicating the main story of last week tonight to the topic of kidney dialysis, he was risking the entire audience lunging for the remote and switching to "literally anything else.” however, he clearly thought the topic was important enough ...