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metastatic cancer cells modify bone remodeling with small rna secretion in bone




image: in the bone metastatic microenvironment, the crosstalk between metastasized cancer cells and the surrounding bone cells is critical for the formation of the osteoblastic or osteolytic phenotype. micrornas are transferred... view more credit: department of physiology and cell biology,tmdures...



cancer metastasis: cell polarity matters




not only the number of migrating cancer cells determines the risk for metastasis but also their characteristics, scientists from the german cancer research center (dkfz) have now reported in nature communications. for circulating cancer cells to be able to invade tissues and settle at other sites in...



metastatic breast cancer cells use hedgehog to 'evilize' docile neighbors




image: heide ford, phd, david f. and margaret turley grohne chair in basic/translational cancer research, associate director for basic research at the university of colorado cancer center view more credit: university of colorado cancer centera university of colorado cancer center study published t...



method may help myeloma patients avoid painful biopsies




multiple myeloma is a cancer of the plasma cells, which are white blood cells produced in bone marrow that churn out antibodies to help fight infection. when plasma cells become cancerous, they produce abnormal proteins, and the cells can build up in bone marrow, ultimately seeping into the bloodstr...



estrogen regulates pathological changes of bones via bone lining cells




the most important female sex hormone, oestrogen, plays a crucial role in the regulation of bone mass. oestrogen deficiency is known to be a major cause of postmenopausal osteoporosis, or bone weakness. skeletal stability and pathological skeletal changes thus depend directly on the hormone's availa...



cancer commandeers immature immune cells to aid its successful spread




image: dr. hasan korkaya and graduate student eunmi lee. view more credit: phil jones, senior augusta university photographer augusta, ga. (april 6, 2017) - more typically, these immature immune cells might help us fight cancer, but scientists have now shown cancer can commandeer the cells to help ...



researchers describe mechanism that underlies age-associated bone loss




image: this is is wei chen, left, and yi-ping li. view more credit: uabbirmingham, ala. - a major health problem in older people is age-associated osteoporosis -- the thinning of bone and the loss of bone density that increases the risk of fractures. often this is accompanied by an increase in fat...



stealing from the body: how cancer recharges its batteries




new research published today uncovers how the blood cancer 'steals' parts of surrounding healthy bone marrow cells to thrive, in work that could help form new approaches to cancer treatment in the future.researchers at the university of east anglia (uea), funded by the rosetrees trust and the big c ...



slu researcher finds cause and possible relief of cancer bone pain




image: daniela salvemini, ph.d., professor of pharmacology and physiology at saint louis university. view more credit: ellen hutti for saint louis universityst. louis -- in a paper published in the journal pain, saint louis university researcher daniela salvemini, ph.d., reports discovering a key ...



study identifies molecules that could help to prevent the development of brain t




image: brain tumor. view more credit: brain tumour researchresearchers from the university of portsmouth's brain tumour research centre of excellence have identified molecules which are responsible for metastatic lung cancer cells binding to blood vessels in the brain. in order for a cancer cell t...



researchers working on blood test to detect brain metastases while still treatab




image: model illustrates clinical implications of bcbm ctc screening method for brain micro-metastasis before they become detectable by mri. bcbm-associated ctcs can be used as a tool to evaluate responses to... view more credit: houston methodisthouston methodist cancer researchers are now closer...



combination immunotherapy effective for advanced prostate cancer




advanced prostate cancer resistant to castration therapy appears to respond well to a combination of immune checkpoint blockades and treatments that target certain immune-busting cells commonly associated with poor patient prognosis and therapy resistance.researchers at the university of texas md an...



scientists give tumor-fighting cells a boost in battling bone marrow cancer




researchers from belgium led by prof. dirk elewaut of the vib-ugent center for inflammation research and the team of prof. vanderkerken and prof. menu at the hematology and immunology lab of the vub uncovered a new way to enhance the function of a specific type of immune cell that destroys tumors in...



chemical array draws out malignant cells to guide individualized cancer treatmen




image: professor kristopher kilian led a research team that developed a chemical array to culture metastatic cancer cells so that different treatments can be tested on them. view more credit: photo by l. brian staufferchampaign, ill. -- melanoma is a particularly difficult cancer to treat once it ...



drug suppresses spread of breast cancer caused by stem-like cells




image: a rare-stem like tumor cell, which plays a critical role in the spread of breast cancer, is identified with immunostaining for the β3 integrin subunit (blue) and transcription factor slug... view more credit: uc san diego healthrare stem-like tumor cells play a critical role in the spread ...



rankl expressed by osteocytes has an important role in orthodontic tooth movemen




tokyo medical and dental university(tmdu) research team demonstrated that osteocytes have a crucial role in orthodontic tooth movement as the major source of receptor activator of nuclear factor-κb ligand (rankl), a protein crucial to bone remodeling.tokyo - during orthodontic tooth movement, osteo...



invasive lung cancer cells display symbiosis -- key to metastasis




image: this is jessica konen at microscope, explaining how she isolates distinctive cells. view more credit: damon meharg/winship cancer institutewhen cancer cells split off from a tumor to seed deadly metastases, they are thought to travel as clusters or packs, a phenomenon known as collective in...



cancer cells send signals boosting survival and drug resistance in other cancer




image: in this image of a human breast tumor, a cluster of malignant cells that have become resistant to chemotherapy are shown in red. view more credit: image courtesy of nciresearchers at university of california san diego school of medicine report that cancer cells appear to communicate to othe...



new study discovers 'killer peptide' that helps eliminate resistant cancer cells




lexington, ky. (aug. 4, 2017) - a new study by university of kentucky markey cancer center researchers shows that when therapy-sensitive cancer cells die, they release a "killer peptide" that can eliminate therapy-resistant cells.tumor relapse is a common problem following cancer treatment, because ...



a new compound targets energy generation, thereby killing metastatic cells




cancer can most often be successfully treated when confined to one organ. but a greater challenge lies in treating cancer that has metastasized, or spread, from the primary tumor throughout the patient's body. although immunotherapy can be effective in treating the metastatic phase of the disease, i...



study provides new insights on bone loss in women




a new study in journal of bone and mineral research looked at the relative contributions of the two types of bone--cortical, or compact bone, and trabecular, or spongy bone--to total bone loss. contrary to the belief that most of the bone loss that occurs during the menopause is trabecular, more tha...



new understanding of why cancer cells move




image: joe w. ramos, deputy director of the uh cancer center. view more credit: university of hawaii cancer centera university of hawai'i cancer center researcher has identified how some cancer cells are made to move during metastasis. the research provides a better understanding of how cancer spr...



another reason to exercise: burning bone fat -- a key to better bone health




image: composite ct scans of mouse femurs are shown. lfd-e refers to low-fat diet plus exercise. dio-e refers to diet-induced obesity plus exercise. red, yellow: less fat in bone. green, blue,... view more credit: m. styner, et alchapel hill, n.c. - it's a fat-burning secret anyone interested in b...



networking is key for cells during bone formation




osteoblasts actively synthesizing osteoid. credit: robert m. hunt; wikipedia.a new study into the way bone cells organise during bone formation could open the door to a better understanding of diseases such as osteoporosis. the research, led by the max planck institute of colloids and interfaces in ...



how cancer metastasis happens: researchers reveal a key mechanism




image: dna (green) residing in fluid outside of cells' main nuclei. view more credit: image credit: wenjing wu/memorial sloan kettering cancer center/naturecancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of dn...