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blood-filtering organs fight infections that enter through the skin




new information about how and where the innate immune system fights off viral infections that enter through the skin could lead to better treatments for viruses like zika, dengue and measles, according to penn state college of medicine researchers. the innate immune system is the body's first line o...



the sting of death in t cells




the cells of the innate immune system use a signaling pathway comprising sting (stimulator of interferon genes) to detect dna from invading viruses and fight them. however, it is unknown if sting triggers the same or different responses in cells of the adaptive immune system, such as t cells. epfl s...



dna sensor plays critical role in cancer immunotherapy via response to unexpecte




image: this is dr. zhijian 'james' chen, professor of molecular biology and a member of the center for the genetics of host defense. view more credit: ut southwesterndallas - august 23, 2017 - ut southwestern medical center researchers report for the first time that tumors stressed by cancer immu...



clues about immune resolution identified in blood




stopping a wound from bleeding is essential for human health. blood coagulation - in which blood goes from liquid to gel and forms a clot - can prevent excessive bleeding and infection. but exactly what molecular events transpire when blood coagulates has remained somewhat mysterious. using a new pr...



scientists discover how obesity stops 'guardian immune cells' from doing their j




scientists have uncovered the physiological mechanics underlying inflammation and obesity by tracking the actions of 'guardian immune cells' in response to changes in diet. they believe their work may herald a new era of research now that they have new therapeutic targets to prevent and control obes...



immune cells derived from specialised progenitors




image: prof. dr. joachim schultze, patrick günther and dr. andreas schlitzer from limes-institute at university of bonn. view more credit: © photo: volker lannert/uni bonndendritic cells are gatekeepers of immunity and are crucial for the detection and initiation of immunity against pathogens an...



neuro-immune crosstalk in allergic asthma




exactly how asthma begins and progresses remain a mystery, but a team led by researchers at brigham and women's hospital and the broad institute of mit and harvard has uncovered a fundamental molecular cue that the nervous system uses to communicate with the immune system, and may potentially trigge...



alzheimer's disease risk linked to a network of genes associated with myeloid ce




many genes linked to late-onset alzheimer's disease (ad) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the icahn school of medicine at mount sinai and published june 19 in the journal nature neuroscience.mount sinai researchers led an internatio...



new bacterial defense mechanism of the crispr-cas system uncovered




a hairpin loop from a pre-mrna. highlighted are the nucleobases (green) and the ribose-phosphate backbone (blue). note that this is a single strand of rna that folds back upon itself. credit: vossman/ wikipediaresearchers led by martin jinek of the university of zurich have found an unprecedented me...



e-cigarettes may trigger unique and potentially damaging immune responses




image: e-cigarettes may not be healthier alternative to traditional cigarettes. view more credit: atsoct. 18, 2017--e-cigarettes appear to trigger unique immune responses as well as the same ones that cigarettes trigger that can lead to lung disease, according to new research published online in t...



researchers discover new mechanism for battling influenza




image: this is a student getting a flu shot on cu boulder campus. view more credit: university of coloradonov. 8, 2017 - just as flu season swings into full gear, researchers from the university of colorado boulder and university of texas at austin have uncovered a previously unknown mechanism by ...



oregon study finds that microbial dispersal impacts animal guts




eugene, ore. -- oct. 3, 2017 -- in a special experiment, zebrafish with defective immune systems swam and dined with counterparts with normal immune systems. in short order, their gut microbiomes became similar. the experiment at the university of oregon was designed to test, at a fundamental level,...



researchers reprogram immune cells to treat psoriasis and more




a new study details the successful reprogramming of certain immune cells that could lead to treatments for autoimmune diseases like psoriasis. the work was performed by researchers with the gladstone institutes, and it is made possible by a ‘small-molecule drug’ that essentially converts immune ...



study examines effects of spaceflight on immune system




expedition 30 crew members dan burbank and andre kuiper perform blood draws for the integrated immune investigation. data collected during the functional immune study will build upon findings from this investigation. credit: nasagetting sick isn't fun for anyone, but it could be especially taxing fo...



scientists light the way for immune system to attack cancer




the science behind harnessing the immune system to fight cancer is complicated, but a university of rochester medical center laboratory discovered a simple, practical way to use light and optics to steer killer immune cells toward tumors. in a study published by the online journal nature communicati...



study examines effects of spaceflight on immune system




getting sick isn't fun for anyone, but it could be especially taxing for crew members aboard the international space station. protecting crew health is important as nasa prepares for long duration, deep-space missions. functional immune, a new investigation taking place in the orbiting laboratory, s...



advancing cancer immunotherapy with computer simulations and data analysis




image: this is a scanning electron micrograph of a human t lymphocyte (also called a t cell) from the immune system of a healthy donor. immunotherapy fights cancer by supercharging the... view more credit: niaidthe body has a natural way of fighting cancer - it's called the immune system, and it i...



mum's immune response could trigger social deficits for kids with autism




the retrospective cohort study of 220 australian children, conducted between 2011-2014, indicates that a "an immune-mediated subtype" of autism driven by the body's inflammatory and immunological systems may be pivotal, according to the university of sydney's professor adam guastella.autism spectrum...



fish provide insight into the evolution of the immune system




new research from the university of east anglia (uea), uk, and dalhousie university, canada, reveals how immune systems can evolve resistance to parasites.



gut bacteria may make or break your chances of cancer treatment working




enlarge/ after fecal transplants from responding humans, the gut cells of mice (blue) were flooded with cancer-fighting immune cells (red, green) dr. luigi nezi]share this storynew, potent cancer therapies can act like daggers pressed into the hindquarters of the immune system, prodding it to lunge ...



immunosuppression underlies resistance to anti-angiogenic therapy




a massachusetts general hospital (mgh) research team has identified a novel mechanism behind resistance to angiogenesis inhibitors - drugs that fight cancer by suppressing the formation of new blood vessels. in their report published in the journal of clinical investigation, the team based in the ed...



viruses up their game in arms race with immune system




in a classic example of the evolutionary arms race between a host and a pathogen, the myxoma virus—introduced to control the rabbit population in australia in 1950—has developed a novel and deadly ability to suppress the immune response of its host rabbits. new research shows that viruses collec...



lab mice may not be effective models for immunology research




the findings have implications for all aspects of medical and scientific research because laboratory mice underpin studies whose results have a transformative effect on human and animal lives through vaccination and other immune-based therapies.professor mark viney and colleagues from the university...



study identifies new metabolic target in quest to control immune response




image: the discovery by ayel amiel, assistant professor at the university of vermont in the department of medical laboratory and radiation science, that dendritic cells have an internal source of... view more credit: sally mccaya surprising discovery that immune cells possess an internal warehouse...



subduing the rebellion: unmasking rogue cells in the immune system




the immune system is a formidable defense against microbial intruders, identifying and eliminating the threats through an extremely intricate and adaptable network of specialized cells. however, a system of such mind-boggling complexity is also prone to misfire. due to genetic mutations for example,...