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study identifies african-specific genomic variant associated with obesity




an international team of researchers has conducted the first study of its kind to look at the genomic underpinnings of obesity in continental africans and african-americans. they discovered that approximately 1 percent of west africans, african-americans and others of african ancestry carry a genomi...



what's a knot—and what's not—in genomic mapping




a depiction of a part of a simulated dna molecule within a nanochannel. the green beads are an unknotted portion of the molecule and the orange beads are a knot. credit: jain and dorfmanwhile dna sequencing provides precise, nucleotide-by-nucleotide genomic information, genome mapping provides a big...



molecular 'on switch' could point to treatments for pediatric brain tumor




massachusetts general hospital (mgh) researchers have identified a mechanism that controls the expression of genes regulating the growth of the most aggressive form of medulloblastoma, the most common pediatric brain tumor. in their report published online in cancer discovery, the team also identifi...



wheat genomics comes of age




most humans consume the grain from 50 wheat plants daily providing them with roughly 20% of their calorific and 25% of their protein intake (www.fao.org/faostat). despite its global importance, wheat has lagged behind other cereals such as rice and maize in the application of genomic tools for its ...



principles of 3-d genome folding and gene expression studied across species




it seems like a feat of magic. human dna, if stretched out into one, long spaghetti-like strand, would measure 2 meters (six feet) long. and yet, all of our dna is compacted more than 10,000 times to fit inside a single cell. how is this accomplished while preserving the overall, vital genomic organ...



researchers find chromosome cooperation is long-distance endeavor




multiple genomic elements work cooperatively and over long distances in order to ensure the proper functioning of chromosomes, a team of scientists has found. its research offers new insights into the complexity of gene regulation.



nuclear architecture emerges at the awakening of the genome




a depiction of the double helical structure of dna. its four coding units (a, t, c, g) are color-coded in pink, orange, purple and yellow. credit: nhgrithe dna molecules in each one of the cells in a person's body, if laid end to end, would measure approximately two metres in length. remarkably, how...



how dinosaurs may have evolved into birds




microraptor. credit: utako kikutanitohoku university researchers and their international collaborators have identified a possible genetic mechanism underlying the evolution of birds, according to a recently published study in nature communications. studies of dinosaur fossils that show bird-like tra...



genetic analysis better explains how uterine cancers resist treatment




researchers have charted the complex molecular biology of uterine carcinosarcoma, a rare and aggressive gynecologic cancer, according to a study published on march 13 in cancer cell. using this new collection of genomic information, physicians will be better able to determine the specific genetic fi...



wooly mammoths experienced ‘genomic meltdown’ before extinction




a new study details the severe evolutionary changes that affected the wooly mammoth shortly before it went extinct. among those changes, researchers have found that wooly mammoths experienced a great reduction in their ability to smell, as well as changes that produced a satin fur coat and other thi...



researchers find chromosome cooperation is long-distance endeavor




human chromosomes during metaphase. credit: steffen dietzel/wikipediamultiple genomic elements work cooperatively and over long distances in order to ensure the proper functioning of chromosomes, a team of scientists has found. its research offers new insights into the complexity of gene regulation....



rarely studied gene usf3 plays role in predisposition to thyroid cancer




image: this is charis eng, m.d., ph.d., chair of the genomic medicine institute, cleveland clinic's lerner research institute. view more credit: cleveland clinicmarch 27, 2017, cleveland: charis eng, m.d., ph.d., of cleveland clinic and her team have discovered that a faulty, rarely studied gene ca...



the proteins that domesticated our genomes




epfl scientists have carried out a genomic and evolutionary study of a large and enigmatic family of human proteins, to demonstrate that it is responsible for harnessing the millions of transposable elements in the human genome. the work reveals the largely species-specific gene-regulatory networks ...



researchers develop new capabilities for genome-wide engineering of yeast




image: university of illinois steven l. miller chair of chemical and biomolecular engineering huimin zhao, left, with carl r. woese institute for genomic biology research fellow tong si in front of... view more credit: kathryn faithone of humankind's oldest industrial partners is yeast, a familiar...



researchers develop new capabilities for genome-wide engineering of yeast




university of illinois steven l. miller chair of chemical and biomolecular engineering huimin zhao, left, with carl r. woese institute for genomic biology research fellow tong si in front of the illinois biological foundry for advanced biomanufacturing (ibiofab) robotic system. credit: kathryn faith...



researchers reveal bioelectric patterns guiding worms' regenerative body plan af




after being treated with an inhibitor of electrical synapses, about 25 percent of wild-type (wt) flatworms regenerated into double-headed forms (dh), while 72 percent regenerated as seemingly normal one-headed worms (crpt). but further analysis showed that the normal-appearing flatworms in fact cont...



researchers use dna-based nano-tweezers to measure the forces between nucleosome




the mode of packaging of the genomic dna in the cell nucleus determines patterns of gene expression. munich researchers have used dna-based nano-tweezers to measure the forces between nucleosomes, the basic packing units of nuclear dna.



new protein regulated by cellular starvation




researchers at the center of genomic integrity, within the institute for basic science (ibs), have found out an unexpected role for a protein involved in the dna repair mechanism. the protein shprh not only helps to fix mistakes generated during dna replication, but also contributes to the generatio...



genomics tracks migration from lost empires to modern cities




new genomic tools are enabling researchers to overturn long-held beliefs about the origins of populations, a researcher will tell the annual conference of the european society of human genetics today (monday). dr eran elhaik, assistant professor of animal and plant sciences at the university of shef...



excessive dna replication and its potential use against cancer




dna over-replication is a phenomenon that can have devastating consequences for proliferating cells. when parts of the genome are duplicated more than once, cells suffer from 'genomic instability' (alterations to the structure, composition and/or number of chromosomes), and this process gives rise t...



pitt study provides clues to relationship between schizophrenia and rheumatoid a




pittsburgh, feb. 24, 2017 - an in-depth computational analysis of genetic variants implicated in both schizophrenia and rheumatoid arthritis by researchers at the university of pittsburgh points to eight genes that may explain why susceptibility to one of the disorders could place individuals at low...



many genetic changes can occur early in human development




image: this is dr. pengfei liu holding human dna treated with fluorescent dyes prepared for copy number variant analysis. view more credit: baylor college of medicinethe genetic material of an organism encodes the instructions that guide its development. these codes are not written in stone; they c...



step forward in fight to rid victorian hospitals of deadly superbugs




not only did mark hanson become a paraplegic at age 22, the nightmare continued when he caught a superbug in hospital afterwards.the now 27-year-old is trying to get on with his life but keeps having to go on stronger antibiotics and fears he might die. mark hanson almost died from a superbug.  pho...



step forward in fight to rid victorian hospitals of deadly superbugs




not only did mark hanson become a paraplegic at age 22, the nightmare continued when he caught a superbug in hospital afterwards.the now 27-year-old is trying to get on with his life but keeps having to go on stronger antibiotics and fears he might die. mark hanson almost died from a superbug.  pho...



new protein regulated by cellular starvation




image: shprh (green) is localized inside the nucleus (blue), in particular in areas called nucleoli (red). the nucleoli are also the locations where ribosomes (the cell's protein factories) are synthetized. shprh... view more credit: ibsresearchers at the center of genomic integrity, within the ins...