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fighting cancer with cancer: 3-d cultured cells could drive precision therapy




ann arbor--honeycomb-like arrays of tiny, lab-grown cancers could one day help doctors zero in on individualized treatments for ovarian cancer, an unpredictable disease that kills more than 14,000 women each year in the united states alone.a team of researchers has devised a process that can grow hu...



new study discovers 'killer peptide' that helps eliminate resistant cancer cells




lexington, ky. (aug. 4, 2017) - a new study by university of kentucky markey cancer center researchers shows that when therapy-sensitive cancer cells die, they release a "killer peptide" that can eliminate therapy-resistant cells.tumor relapse is a common problem following cancer treatment, because ...



cancer-fighting t cells are smarter, stronger than experts thought




scientists studying the body's cancer-fighting t cells have a serious problem: when they culture them in the lab, the t cells sit around at equilibrium, waiting to bump into cancerous cells. but that's not how they operate inside the body. there, they are motorized little bloodhounds, actively seeki...



maze-like chip helps spot aggressive cancer cells




and importantly, it's much faster than conventional methods, which use markers and traps to gradually bind cancer cells. blood flows quickly, so you're only waiting minutes to pinpoint the cancer. and if you need better results than you got the first time around, you just have to add another chip.th...



combination therapy could provide new treatment option for ovarian cancer




researchers have been trying to understand why up to 85 percent of women experience recurrence of high-grade serous ovarian cancer -- the most common subtype of ovarian cancer -- after standard treatment with the chemotherapy drug carboplatin. preclinical research from dr. sanaz memarzadeh, who is a...



the fda just approved a new cancer treatment using car t gene therapy




immune-based cancer treatments are surging forward as the food and drug administration (fda) on wednesday approved the second of a new technology called car t, this time to treat diffuse large b-cell lymphoma, a type of non-hodgkin lymphoma. in august, the agency approved the first car t cell therap...



fred hutch scientists to cover advances in immunotherapy, proteomics at aacr




scientists from the fred hutchinson cancer research center in seattle are scheduled to present and discuss the latest developments in immunotherapy and proteomics at the american association for cancer research annual meeting, research propelling cancer prevention and cures, on april 1-5. what follo...



new three-in-one blood test opens door to precision medicine for prostate cancer




scientists have developed a three-in-one blood test that could transform treatment of advanced prostate cancer through use of precision drugs designed to target mutations in the brca genes.by testing cancer dna in the bloodstream, researchers found they could pick out which men with advanced prostat...



combination immunotherapy effective for advanced prostate cancer




advanced prostate cancer resistant to castration therapy appears to respond well to a combination of immune checkpoint blockades and treatments that target certain immune-busting cells commonly associated with poor patient prognosis and therapy resistance.researchers at the university of texas md an...



supercomputers assist in search for new, better cancer drugs




surgery and radiation remove, kill, or damage cancer cells in a certain area. but chemotherapy—which uses medicines or drugs to treat cancer—can work throughout the whole body, killing cancer cells that have spread far from the original tumor.



scientists light the way for immune system to attack cancer




the science behind harnessing the immune system to fight cancer is complicated, but a university of rochester medical center laboratory discovered a simple, practical way to use light and optics to steer killer immune cells toward tumors. in a study published by the online journal nature communicati...



gut bacteria may make or break your chances of cancer treatment working




enlarge/ after fecal transplants from responding humans, the gut cells of mice (blue) were flooded with cancer-fighting immune cells (red, green) dr. luigi nezi]share this storynew, potent cancer therapies can act like daggers pressed into the hindquarters of the immune system, prodding it to lunge ...



new study reveals breast cancer cells recycle their own ammonia waste as fuel




at a glance: breast cancer cells secrete ammonia as a byproduct of cellular metabolism, which accumulates in the tumor's surrounding environment.new study in mice and cultured tumor cells by harvard medical school researchers reveals tumors can use this ammonia as a fuel source.repressing ammonia me...



advanced prostate cancer treatment failure due to cell reprogramming




new york, ny (may 4, 2017)--columbia university medical center (cumc) researchers have discovered a molecular mechanism that reprograms tumor cells in patients with advanced prostate cancer, reducing their response to anti-androgen therapy. the findings, based on a study in mice, could help to deter...



scientists discover mechanism that causes cancer cells to self-destruct




many cancer patients struggle with the adverse effects of chemotherapy, still the most prescribed cancer treatment. for patients with pancreatic cancer and other aggressive cancers, the forecast is more grim: there is no known effective therapy.a new tel aviv university study published last month in...



fdg-pet/ct predicts melanoma patients' response to immune checkpoint inhibitor t




image: these are proposed criteria for early prediction of eventual response to ici therapy incorporating recist-based and percist-based changes seen 3-4 weeks into treatment. patients whose ct scans, performed 3-4 weeks... view more credit: sy cho, ej lipson, h im, et al., johns hopkins universit...



castration-resistant prostate cancer cell growth impeded by endostatin




image: this is joo hyoung lee (left) and selvarangan ponnazhagen. view more credit: uabbirmingham, ala. - failure of hormone deprivation therapy, which is used to slow prostate cancer in patients, leads to castration-resistant prostate cancer, a lethal form of advanced disease with limited treatmen...



researchers discover new immunotherapy combination effective at killing cancer c




image: this is doug mahoney, phd. view more credit: photos provided by doug mahoney's labimmunotherapy is an emerging field in the global fight against cancer, even though scientists and clinicians have been working for decades to find ways to help the body's immune system detect and attack cancer...



breakthrough cancer treatment brings hope and challenges




the first gene therapy for cancer, approved by the food drug administration in august, will transform the treatment of a particular kind of cancer in children and young adults. it's transformative because it uses a patient's own immune cells to attack the cancer cells. the hope is that this is just ...



new study: aggressive breast cancer grows faster in obese environment




it's not just what's inside breast cancer cells that matters. it's also the environment surrounding cancer cells that drives the disease, according to researchers at the university of north carolina lineberger comprehensive cancer center. in an abstract that will be presented april 3 at the american...



chemical array draws out malignant cells to guide individualized cancer treatmen




image: professor kristopher kilian led a research team that developed a chemical array to culture metastatic cancer cells so that different treatments can be tested on them. view more credit: photo by l. brian staufferchampaign, ill. -- melanoma is a particularly difficult cancer to treat once it ...



engineering non-immune cells to kill cancer cells




t-cells are one of the immune system's major weapons. they detect the body's cells infected with a virus and trigger their ablation, effectively killing the virus. t-cells cannot do the same with cancer cells, however, as they do not recognise them as foreign cells and are therefore unable to elimin...



new prospects on the spread of tumors




in cancer therapy, the prevention of tumour spread is one of the greatest challenges.cancer cells are able to change their micro- environment physico-chemically and adapt their movement behaviour according to the new conditions. this is where the researchers have found an appropriate solution: using...



research study gives new insight into how cancer spreads




a research study led by university of minnesota engineers gives new insight into how cancer cells move based on their ability to sense their environment. the discovery could have a major impact on therapies to prevent the spread of cancer. the research is published in nature communications, a leadin...



fast capture of cancer markers will aid in diagnosis and treatment




a nanoscale product of human cells that was once considered junk is now known to play an important role in intercellular communication and in many disease processes, including cancer metastasis. researchers at penn state have developed nanoprobes to rapidly isolate these rare markers, called extrace...