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advanced prostate cancer treatment failure due to cell reprogramming




image: in mice with an aggressive form of prostate cancer, treatment with abiraterone -- a commonly used drug for advanced prostate cancer -- increased the size of the tumors compared to no treatment. view more credit: cory abate-shen and michael shen / columbia university medical centernew york, ...



advanced prostate cancer treatment failure due to cell reprogramming




new york, ny (may 4, 2017)--columbia university medical center (cumc) researchers have discovered a molecular mechanism that reprograms tumor cells in patients with advanced prostate cancer, reducing their response to anti-androgen therapy. the findings, based on a study in mice, could help to deter...



castration-resistant prostate cancer cell growth impeded by endostatin




image: this is joo hyoung lee (left) and selvarangan ponnazhagen. view more credit: uabbirmingham, ala. - failure of hormone deprivation therapy, which is used to slow prostate cancer in patients, leads to castration-resistant prostate cancer, a lethal form of advanced disease with limited treatmen...



are men with a family history of prostate cancer eligible for active surveillanc




active surveillance--careful monitoring to determine if or when a cancer warrants treatment--is an increasingly prevalent choice for prostate cancer, but it's unclear if the strategy is appropriate for men with a family history of prostate cancer. a recent analysis of the medical literature conclude...



new molecules may offer treatment option for some aggressive prostate cancers




orlando -- novel molecules called selective androgen receptor degraders (sards) may offer the next generation of treatment options for advanced prostate cancer, a new industry-sponsored study reports. the results of this research will be presented saturday, april 1, at endo 2017, the 99th annual mee...



fluciclovine pet/ct improves radiotherapy targeting for recurrent prostate cance




image: ctvpost (red) = ctvpre (yellow) union ctvpet (pink). also shown (upper right corner) are the pre (square) vs post (triangle) dose volume histograms for ptv1, ptv2, rectum, bladder, and penile... view more credit: ashesh b. jani, md, and david schuster, md, emory university.reston, va. (march...



heart failure is as 'malignant' as some common cancers




a new analysis finds that, despite advances in care, men and women with a diagnosis of heart failure continue to have worse survival rates than patients with certain common cancers.the study included 56,658 adults in scotland who were receiving care in a primary care setting, with a total of 147,938...



combination immunotherapy effective for advanced prostate cancer




advanced prostate cancer resistant to castration therapy appears to respond well to a combination of immune checkpoint blockades and treatments that target certain immune-busting cells commonly associated with poor patient prognosis and therapy resistance.researchers at the university of texas md an...



biomarker could lead to personalized therapies for prostate cancer




columbia, mo. - in 2016, more than 181,000 new cases of prostate cancer were reported in the u.s., according to the american cancer society. the prostate-specific antigen (psa) test is one of the earliest ways clinicians can detect prostate cancers in their patients. sometimes, a high psa level may ...



genetic association with aggressive prostate cancer discovered




image: dr. alexandre zlotta led the study identifying a genetic association with aggressive prostate cancer. view more credit: courtesy of mount sinai hospital, toronto, canadamarch 16, 2017 (toronto) - an international study published in the journal of the national cancer institute has identified ...



yoga reduces side effects of prostate cancer treatment




elizabeth renstrom for timeresearchers have put yoga to the scientific test for years, and the results so far have been impressive. the practice has been shown to lower risk for heart disease, type 2 diabetes, depression and hypertension.but yoga can also help those who are already ill feel better. ...



prostate cancer trial shows treating with precision radiotherapy cuts course of




image: this is dr. charles catton, radiation oncologist, princess margaret cancer centre, university health network. view more credit: uhn(toronto, canada - march 16, 2017) - an ontario-led international clinical trial with 1,206 men with localized prostate cancer shows that compressing radiation t...



clinical trial shows benefit of yoga for side effects of prostate cancer treatme




image: this is a penn yoga session. view more credit: penn medicinephiladelphia - men who attended a structured yoga class twice a week during prostate cancer radiation treatment reported less fatigue and better sexual and urinary function than those who didn't, according to a clinical trial led by...



non-invasive prostate cancer diagnosing, monitoring




ph.d. student parissa ziaei prepares silica nanosprings for a prostate cancer detection device in su ha's lab at the gene and linda voiland school of chemical engineering and bioengineering at wsu. credit: washington state universitytechnology being developed at washington state university provides ...



combination therapy could provide new treatment option for ovarian cancer




researchers have been trying to understand why up to 85 percent of women experience recurrence of high-grade serous ovarian cancer -- the most common subtype of ovarian cancer -- after standard treatment with the chemotherapy drug carboplatin. preclinical research from dr. sanaz memarzadeh, who is a...



palbociclib in advanced breast cancer: disadvantages predominate in certain pati




palbociclib (trade name: ibrance) has been approved since november 2016 for the treatment of women with advanced hormone receptor-positive breast cancer who are not eligible for chemotherapy, radiotherapy or further surgery. in an early benefit assessment, the german institute for quality and effici...



trial: abiraterone acetate responses even after initial hormone therapy failure




image: thomas flaig, md, is national primary investigator on clinical trial showing 13 percent response to abiraterone acetate in metastatic prostate cancer patients previously non-responding to hormone therapy view more credit: university of colorado cancer centerpatients with metastatic prostate ...



penn researchers use new imaging to show key enzyme in ovarian cancer




philadelphia - a new imaging test may provide the ability to identify ovarian cancer patients who are candidates for an emerging treatment that targets a key enzyme cancer cells need to survive. currently, epithelial ovarian cancer patients with brca1 mutations are considered candidates for the trea...



advanced form of proton therapy shows promise for treating lung cancer recurrenc




an advanced form of image-guided radiation therapy, known as intensity modulated proton therapy (impt), has shown early promise for the treatment of recurrent lung cancer, according to new research from the university of texas md anderson cancer center. researchers found that after reirradiation wit...



fda oks new novartis drug for type of advanced breast cancer




in a saturday, aug. 13, 2016 file photo, logo of swiss pharmaceutical company novartis is seen at the novartis korea office in seoul, south korea. u.s. regulators have approved a new drug as an initial treatment for postmenopausal women with a type of advanced breast cancer.



stem cell reprogramming factor controls change in cellular energy generation




university of tsukuba-led researchers explored the function of the reprogramming factor klf4 in production of induced pluripotent stem cells (ipscs). klf4 was shown to bind upstream of the tcl1 target gene, which controls a metabolic change in energy generation during the acquisition of cellular plu...



prevention and prediction: understanding how lung cancer progresses




philadelphia - treating the brain with a preventative course of radiation may help small cell lung cancer (sclc) patients - whose tumors often spread to their brain -- live longer, according to a new study from researchers in the abramson cancer center and perelman school of medicine at the universi...



a light breakfast can cut some cancer drug doses, dutch researchers say




although pharmaceutical firms recommend that many anti-cancer drugs should be taken on an empty stomach, researchers at radboud teaching hospital in nijmegen say a light breakfast can actually reduce the need for high doses of medicine, the volkskrant reported on monday.the research project is one o...



nonsurgical treatment for enlarged prostate remains effective for years




washington (march 8, 2017) -- a minimally invasive treatment that reduces urinary tract symptoms for men with enlarged prostates maintains its effectiveness for at least three years after patients undergo the therapy, according to research being presented at the society of interventional radiology's...



penn studies find promise for innovations in liquid biopsies




image: this is a cluster of three circulating tumor cells. view more credit: penn medicinephiladelphia - from using fluid in the lungs to better understand the potential of immunotherapy treatments in lung cancer, to tracking circulating tumor cells in prostate cancer, to conducting rna sequencing ...